rookie wide receiver is out for the season after suffering ligament damage in his left ankle during Monday night's win against Miami, the team announced Tuesday.
Per ESPN, the Brooklyn-native Samuel will have surgery on the ankle, but no date has yet been set for the procedure.
"The second-round pick out of Ohio State was just coming into his own after spending most of training camp and a portion of the first month of the season dealing with a hamstring injury and later an injury to the right ankle," wrote ESPN.
Coach Ron Rivera said earlier Tuesday there was concern that Samuel's injury would be season-ending, but he was awaiting MRI results.
"They weren't very optimistic," Rivera said.
Samuel had a season-high five catches on seven targets for 45 yards against Miami before suffering the injury, which occurred when a defender rolled over the ankle on a pass into the end zone. He had only 10 catches for 70 yards before Monday night.
Offensive coordinator Mike Shula said Samuel will be replaced by, and even running back .
"Is there anybody as fast as him?'' Shula said of Samuel. "... We're going to try hard to find ways to put guys in what they do best and then have them go do it.''
The good news for Carolina is Pro Bowl tight end(broken foot) is set to come off injured reserve after this week's bye. He should be ready for the Nov. 26 game against the .
Also, speedy receiver(broken arm) is set to come off injured reserve after the Jets game.